How did new biochemical pathways, which involve multiple enzymes working together in sequence, originate? Every pathway and nano-machine requires multiple protein/enzyme components to work. How did lucky accidents create even one of the components, let alone 10 or 20 or 30+ at the same time, often in a necessary programmed sequence? Evolutionary biochemist Franklin Harold wrote, “we must concede that there are presently no detailed Darwinian accounts of the evolution of any biochemical or cellular system, only a variety of wishful speculations.”
I have learned that Jim Pappa is the author of the quote above so I want to give him the thanks and credit.